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Faculty Position - Cell Therapy and Cancer Immunology

Requisition ID: 2023-47383
Overview: The Cell Therapy and Cancer Immunology program in the Abigail Wexner Research Institute at Nationwide Children's Hospital is expanding its faculty. The mission of the CTCI program is to bring novel cellular therapies to children and young adults with cancer or other inherited or acquired conditions (e.g., hematopoietic, infectious, immunologic, etc) through scientific discovery, cellular and genetic engineering, and efficient manufacturing for rapid translation to the clinic. More information is available at: | | Cell Therapy and Cancer Immunology Program | | About the Faculty Position | - Seeking applicants at the Assistant, Associate, or Full Professor level with an independent laboratory research program focused on cellular therapy and/or related immunobiology | - Tenure-track faculty appointment in Department of Pediatrics, The Ohio State University | - Broad collaborative research potential throughout the Abigail Wexner Research Institute | - Consideration of joint positions in Centers for Vaccines and Immunity, Childhood Cancer, or Gene Therapy | | Qualifications Required | - MD, MD/PhD, or PhD | - Track record of grant funding | - Track record of high quality first- or senior-author research publications relevant to cell-based therapies | | About the CTCI Program | - Rapid growth- developed over 30 IND applications, 15 investigator-initiated cell therapy trials, 10 investigational cell therapy products, and over 60 patients treated with cellular therapy in 5 years | - Program integration with OSUCCC and the Pelotonia Institute for Immuno-Oncology | - CTCI infrastructure supports clinical trial development, IND preparation and submission, and GMP development/manufacturing of clinical-grade therapeutics | - Central manufacturing of investigation products for multi-institutional trials | | Send correspondence, including curriculum vitae, a brief statement of research interests, and contact information for three references to Patrick.Kennedy@nationwidechildrens.org in Faculty Recruitment | | About the Research Institute: | - Top ten among free-standing children’s hospitals for NIH funding | - Designed for collaboration, creativity, and team science | - Comprehensive resources including regulatory support, tech transfer, genomics, and GMP facility | - 20 investigators hired in 2022 | - Nearly 200 investigators total | About Nationwide Children's Hospital: | - Among largest pediatric hospitals in the US: 1M+ patient visits annually | - Nationally recognized for diversity and inclusion | - US News & World Report Honor Roll hospital | - 1500+ total medical faculty | About Columbus, Ohio: | - State capital with 2M+ population | - Forbes #1 rising city for startups | - Outstanding quality of life and cost of living | Through our diversity, we achieve the highest standards of inclusiveness and create a culture that respects individual differences. It is the cornerstone of our strategic plan and how we attract the best people to ensure the best programs. To build a diverse workforce, Nationwide Children’s encourages applications from individuals with disabilities, minorities, veterans, and women. EEO/AA employer.

IGM Post Doctoral Scientist - Rajappa lab

Requisition ID: 2023-45740
Overview: Post Doctoral Scientist - IGM Rajappa Lab | | | Applicants should have either a PhD or MD from backgrounds in Neuroscience, Tumor Immunology or Cancer Biology. Backgrounds in Molecular, Cellular and Developmental Biology will also be considered. Experience with animal tumor modeling, cell sorting and flow cytometry is desired. Additional experience with Genomics/Bioinformatics/Statistics is a plus. | | Our vision aims to rapidly translate research discoveries into lasting treatment options for pediatric and young adult patients afflicted with Central Nervous System (CNS) tumors. Specifically, our laboratory is studying the mechanisms that potentiate low to high grade glioma progression. We use transgenic brain tumor mouse models that recapitulate low to high grade glioma progression and correlate our findings with peripheral blood and tumor specimens from patients with CNS tumors. These models also serve as a platform to explore the contribution of the tumor microenvironment and myeloid cells in low grade glioma progression and also test novel therapeutic agents aimed at impairing malignant transformation. To that end, we aim to develop next-generation therapies that modulate the innate immune myeloid cell rich glioma microenvironment. To dissect myeloid cell heterogeneity within gliomas, our lab leverages Next-Generation Sequencing in addition to Single-cell RNA sequencing to elucidate the functional role of these innate immune populations. | | Our long-term goals are to use these innovative tools in order to translate our findings into new age clinical trials for patients with gliomas and validate select myeloid cell populations as in-vivo biomarkers that may enhance risk stratification and targeted approaches for this patient population. | | Our team is part of the Institute for Genomic Medicine (IGM) at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, which is at the forefront of using genomic sequencing in the clinical setting to predict best health outcomes for patients and is one of the driving forces shaping precision medicine. Led by a team of internationally-renowned genomic medicine scientists (Richard Wilson, PhD and Elaine Mardis, PhD) IGM is housed in the campus’ newest research building, spanning ~25,000 square feet of laboratory and office space in a highly interactive setting. | | Please include “Translational Neuro-Oncology Research Scientist Position” in the subject line. Competitive applications will be evaluated when they are received and the position will remain open until the position is filled. | | The Research Scientist position will design and lead scientific aspects of a project, such as study design, grant proposal drafting, outcome evaluation, and manuscript writing etc. The candidate must have strong interpersonal skills and capable of working with technical staff to drive the projects forward. The candidate must be able to verbally and visually communicate clearly to all level of stakeholders. | | From the results of studies, helps to develop hypotheses for further investigation. With minimal guidance from the PI, prepares technical materials such as abstracts, annual reports, scientific papers, grants, and presentations. Publishes scientific articles in appropriate refereed journals.

Research Associate - Research Childhood Cancer - Stanton lab

Requisition ID: 2023-43659
Overview: Conducts independent research within a general area decided upon in conjunction with a Principal Investigator; prepares position papers and research reports; assists in the preparation of scientific publications and research grant proposals; prepares budget proposals for conducting research studies.

Research Assistant - RI Childhood Cancer Chang

Requisition ID: 2023-43612
Overview: The qualified individual with a bachelor degree in biochemistry, molecular biology, or related discipline will perform research experiments to study the disease mechanisms of nervous system tumors and evaluate potential therapeutics, assist in analyzing data, prepare and maintain laboratory reports, and assist in preparing publications.

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