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Post Doctoral Scientist Yr 1-3 - IGM Bedrosian

Requisition ID: 2024-49950
Overview: The Bedrosian lab in the Institute for Genomic Medicine is seeking a post-doctoral scientist to join our team. Our translational research group focuses on studying the genetics of epilepsy and other neurodevelopmental diseases using patient-derived tissue as well as murine models. We use cutting-edge techniques including single cell RNA-sequencing, spatial transcriptomics/proteomics, and other genomic techniques. The successful candidate will be engaged in projects exploring the molecular etiology of epilepsies through bioinformatic analysis of single-cell sequencing data and other genomic data. Prior experience with R and Seurat is preferred. The Institute for Genomic Medicine provides a stellar training environment with exposure to world-class expertise in genomics. We are a collaborative group with opportunities to build new skillsets and interact across the institute. Post-doctoral scientist will report to PI.

Post Doctoral Scientist - Gene Therapy/Neuroscience

Requisition ID: 2024-49922
Overview: EMPLOYER: Gene Therapy LaboratoryAbigail Wexner Research Institute, Nationwide Children’s Hospital (NCH). | | LOCATION: Columbus, Ohio, USA | | POSITION TYPE: Full-time | | PREFERRED START DATE: April 2024 | | DISCIPLINE: Gene Therapy | | ORGANIZATION TYPE: Non-profit | | RESEARCH DESCRIPTION: Our group is focused on developing novel gene therapy treatments for neuromuscular disorders and lysosomal storage disorders. We have recently developed and tested a novel gene therapy in patients with Duchenne Muscular Dystrophy and are currently developing treatments for Limb Girdle Muscular Dystrophy Type R9, GNE myopathy, and Lysosomal Acid Lipase Deficiency. This research involves basic and proof of concept studies in animal models for these diseases, as well as safety studies, with the goal of developing IND approvals for the testing of therapies in clinical trials. We collaborate with a team of other laboratories in Center for Gene Therapy and at Ohio State University to accomplish these goals. | | The successful candidate will have an excellent foundation in molecular and cellular biology and also in molecular and cellular pathology. We are particularly interested in candidates who also have experience analyzing animal models of disease and who understand the concepts relevant to design of disease therapies for muscle, liver, and/or brain disorders. As our lab focuses on diseases and therapies involving glycosylation, experience in glycobiology would be a major plus. Expertise in skeletal muscle or cardiac physiology, or AAV biology, would also be a major plus. To apply, please submit curriculum vitae, a cover letter indicating areas of expertise and a detailed statement of research interests and scientific accomplishments, and a list of 3 references. | | The selected candidate will be professional, self-motivated, and dedicated, with strong communication and interpersonal skills that will fit with our highly collaborative team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for children with genetic disorders. | | **This position offers candidates to be involved in basic research and translation to the clinic** | | QUALIFICATIONS: | - Applicants must have an MD, Ph.D., or MD/PhD in a field of Biomedical or Life Sciences. | - Previous experience in a wet lab including work with cell cultures and animal models is required. | | COMPETENCIES, KNOWLEDGE, SKILLS, AND ABILITIES: | - Candidates should be capable of designing and carrying out high-level, complex research experiments independently. | - Expertise in lab techniques including, but not limited to, immunofluorescence, western blotting, ELISA, qPCR, qRT-PCR, flow cytometry, protein biochemistry, glycobiology, etc. | - Applicants with a good track record of publication are desirable, along with effective communication skills and scientific writing skills. | - Ability to train and mentor laboratory staff and graduate students. | - Writing and publishing scientific material, including manuscripts. | - Presenting research at regional, national, and international conferences. | - Contributing to grant submissions for external funding. | | We can offer potential candidates: | - Up to 5 years of salary support, to be renewed annually based on productivity | - Strong mentorship to support career development toward academia or industry jobs | - State-of-the-art laboratories and core facilities | - Possible affiliation with The Ohio State University College of Medicine | - Collaborative initiatives with clinical faculty

Post Doctoral Scientist - Cancer Immunotherapy/Tumor Biology

Requisition ID: 2024-49685
Overview: Dr. Long-Sheng Chang Research Lab | | A postdoctoral position is available in the Chang Research Laboratory within the Center for Childhood Cancer of the Abigail Wexner Research Institute at Nationwide Children’s Hospital. This project will focus on developing novel medical therapies, including targeted therapies and immunotherapies, for the treatment of neurofibromatosis type 2 (NF2)- and neurofibromatosis type 1 (NF1)-associated tumors as well as pediatric soft-tissue and bone sarcomas. Individuals with experience in or willingness to learn tumor biology and signaling, therapeutic evaluation, and multi-omics analysis, as well as those with expertise in molecular and cellular biology and animal models are encouraged to apply. | | Neurofibromatosis (NF) is a group of genetic diseases that predispose individuals to the development of multiple nervous system tumors and other debilitating manifestations. Due to limited treatment options, these NF-associated tumors caused significant morbidity and mortality. To develop a medical therapy for NF-associated tumors, our lab has studied the NF2 tumor-suppressor gene function and expression during development and tumorigenesis. | | We have identified novel NF2 functions and potential druggable targets. Several cell culture and animal models for NF2-associated schwannomas and meningiomas and NF1-related malignant peripheral nerve sheath tumors (MPNSTs) have been generated and used to identify novel targeted drugs or drug combinations that potently suppress tumor growth. Several targeted compounds that we have studied have advanced into clinical trials. In addition, we have identified several eIF4A (eukaryotic initiation factor 4A) inhibitors with potent anti-tumor activities. We have also identified compounds or drugs that highly synergize with these eIF4A inhibitors to eliminate NF-related tumor and multiple types of sarcoma cells. The ultimate goal of our research is to advance these efficacious medical treatments into the clinic, ultimately improving the clinical care and long-term treatment outcomes for these patients

Post Doctoral Scientist - Virology and Immunology

Requisition ID: 2024-49599
Overview: Postdoctoral Research Fellow Positions In Virology and Immunology | | EMPLOYER: Laboratory of Dr. Zongdi Feng, Center for Vaccines and Immunity at Nationwide Children’s Hospital (NCH) and The Ohio State University. | | LOCATION: Columbus, Ohio, USA | | SALARY: Based on NIH Post-doctoral stipend guidelines, benefits include family health insurance, matched retirement account | | POSITION TYPE: Full-time | | DISCIPLINE: Virology, cell biology, biochemistry, immunology, virus-host interactions | | ORGANIZATION TYPE: Non-profit | | Job description: | Multiple PostdoctoralResearch Fellow positions are available at The Ohio State University/Nationwide Children’s Hospital (Columbus, OH) to study virus-host interactions. Hepatitis E virus (HEV) causes both acute and persistent infections in humans resulting in significant morbidity and mortality. HEV has a unique life cycle: it is shed in the feces as naked virions but exists in the bloodstream as ‘quasi-enveloped’ particles that are infectious but not recognizable by circulating HEV-specific antibodies (Nat Rev Microbiol. 2023. PMID: 37185947). | | The first project investigates how quasi-enveloped HEV particles are generated and how they infect new cells. For this project, a strong background in virology and cell biology is required. A second project investigates the role of a recently discovered capsid decoy in HEV life cycle and immunity (PNAS. 2018. PMID: 29669922; Hepatology. 2023. PMID: 37185268). For this project, candidates with experiences in structural biology or immunology will be preferably considered. Experiences in RNA biology or bioinformatics are not required but will be considered a plus. | | Responsibilities: | The successful candidate is expected to have excellent technical and communication skills, perform self-directed research, and assist the PI in preparing manuscripts and grant applications. | | Minimum requirements: | Candidates must have a PhD or equivalent with strong research experience in molecular biology, virology and cell biology, and basic knowledge in immunology. Competitive salary will be commensurate with experience (NIH recommended salary for postdoctoral fellows). Interested applicants should submit a single PDF file consisting of a CV, a brief description of their research achievements and interests, and the contact information of three references to Dr. Zongdi Feng (Zongdi.Feng@nationwidechildrens.org). | | We can offer potential candidates: | - Up to 5 years of salary and project support | - Substantial financial support to develop new ideas | - Strong mentorship to support career development toward academia or industry jobs | - State-of-the-art laboratories and core facilities | - Affiliation with The Ohio State University College of Medicine | - Collaborative initiatives with clinical faculty | | Nationwide Children’s Hospital | Founded in 1892, Nationwide Children’s Hospital has evolved into one of the nation’s leading children’s hospitals. Named as a Top 10 Honor Roll “Best Children’s Hospital” since 2013, Nationwide Children’s is one of America’s largest not-for-profit freestanding pediatric health care systems providing wellness, preventive, diagnostic, treatment, and rehabilitative care for infants, children, and adolescents, as well as adult patients with congenital disease. | In partnership with The Ohio State University College of Medicine, Nationwide Children’s trains, mentors, and advocates for the next generation of pediatricians, pediatric surgeons, pediatric specialists, and research scientists. Ohio State’s Department of Pediatrics is essentially housed at Nationwide Children's.

Post Doctoral Scientist - Pediatric Cancer and Biobehavioral Digital Health

Requisition ID: 2024-49442
Overview: Dr. Micah Skeens Research Program | | We are inviting applications for a funded postdoctoral scholar to join Dr. Micah Skeens’ team at Nationwide Children’s Hospital and The Ohio State University. Our lab is devoted to investigating the psychosocial and biobehavioral outcomes of children facing cancer and undergoing hematopoietic stem cell transplants. Our mission extends beyond research; we strive to develop innovative digital health interventions, with a specific focus on underrepresented and vulnerable populations. We are committed to addressing the unique needs of diverse communities, including those who speak different languages and reside in rural and Appalachian areas. | | In this position, with guidance from Dr. Skeens, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will also include support of existing lab projects, including overseeing data analysis and dissemination, and mentoring and training junior scholars, and grant writing. | | Visit our lab website for more information about our research and team:

Post Doctoral Scientist - Biomedical Imaging and Vascular Biology

Requisition ID: 2024-49107
Overview: Dr. Mitchel Stacy Lab | | A postdoctoral research position is immediately available within the Center for Regenerative Medicine at Nationwide Children’s Hospital working in the lab of Dr. Mitchel Stacy. | | Research in the lab is focused on the development and validation of quantitative imaging techniques that allow for characterization of cardiovascular diseases and vascular remodeling. Of particular interest is PET imaging of skeletal muscle perfusion and PET-based molecular imaging of vascular biology. | | The lab utilizes multiple imaging modalities, which include clinical and microPET/CT, CT angiography, and ultrasound. The lab is equipped with a variety of image processing workstations, which include dedicated software for PET/CT image analysis, ANSYS for computational modeling research, dedicated tools for ultrasound image analysis, and a dedicated angiography workstation. Experimental work and training will be focused on pre-clinical models of vascular disease (small and large animal) and clinical cardiovascular imaging. Clinical imaging projects will be conducted in collaboration with The Ohio State University College of Medicine and additional pediatric hospitals across the United States. | | Candidates should be highly motivated with an interest in biomedical imaging, vascular biology, and/or skeletal muscle biology. Also required are excellent written and verbal communication skills, as the position will involve participation in manuscript and grant writing. | | To apply, interested individuals should send a letter of interest and recent copy of CV to Dr. Stacy at mitchel.stacy@nationwidechildrens.org | For more information related to the lab’s research, please refer to a list of recent publications... | https://www.ncbi.nlm.nih.gov/myncbi/14IZpslMVRrAt/bibliography/public/

Post Doctoral Scientist - Cardiovascular/Heart/Stem Cells

Requisition ID: 2024-48901
Overview: Dr. Deqiang Li Lab | | A fulltime position postdoctoral fellow position is immediately available in Dr. Deqiang Li’s Laboratory, in the Center for Cardiovascular Research at the Nationwide Children’s Hospital (NCH) Research Institute, Ohio State University. This position is supported by a NIH R01 grant. | | Read about Dr. Li's Research Program here: | Deqiang Li (nationwidechildrens.org) | | Research in my laboratory is focused on understanding the mechanisms of cardiovascular development, disease, and regeneration. In particular, we are interested in identifying the novel signaling pathways that regulate myocardial development or govern cardiomyocyte differentiation and maturation by using in vitro and in vivo approaches. | | Cell and mouse model systems, including induced pluripotent stem cells (iPSCs) and conditional gene knockouts will be used in these research projects. Many state-of-the-art techniques are employed, such as CRISPR/Cas9 Genome Editing, AAV, single cell RNA-Seq and ChIP Seq, confocal microscopy, multicolor flow and sorting, surgical models, ultrasonic and telemetric measurements of cardiovascular function in mice.

Post Doctoral Scientist - Cardiovascular/Stem Cells/Genomics

Requisition ID: 2023-47763
Overview: A postdoctoral scientist position is immediately available in Dr. Mingtao Zhao’s laboratory in the Center for Cardiovascular Research at the Nationwide Children’s Hospital and The Ohio State University in Columbus, Ohio. The Zhao lab is using patient-derived induced pluripotent stem cells (iPSCs), CRISPR/Cas9 genome editing, organoids, and single-cell genomics to study the molecular and genetic mechanisms of cardiovascular development and congenital heart disease (Circ Res 2023, PMID: 36583388; Stem Cell Res 2023, PMID: 36599283; Stem Cells 2020, PMID: 32232889; PNAS 2017, PMID: 29203658; Circ Res 2017, PMID: 29030344). | | The goal of the Zhao lab is to elucidate the cause-consequence relationship of a given genetic variant in the contribution of cardiovascular disease using patient-specific iPSCs that retain all genetic information of the affected patients. The Zhao lab is currently funded by the NIH/NHLBI, Additional Ventures, AHA, and Abigail Wexner Research Institute at Nationwide Children’s Hospital. | | Qualifications Required: | | This is a great opportunity for young investigators who aim to establish an independent academic career in the next few years. Successful candidates should have a PhD/MD or equivalent degree (< 3 years after graduation) and should have expertise in cardiac physiology, cardiovascular development, genomics, or organoid biology. Candidates who have additional expertise in bioinformatics or CRISPR/Cas9 genome editing or tissue engineering would be preferred. Individuals who are underrepresented in the biomedical research are encouraged to apply. Candidates will have an opportunity to be funded by an NIH T32 training award. Competitive salary and relocation bonus will be offered for well-qualified candidates. | | The Center for Cardiovascular Research currently has an NIH-funded T32 postdoctoral program to provide interdisciplinary, translational, and state-of-the-art research training in congenital and acquired heart disease, partnered with The Ohio State University College of Medicine. The Abigail Wexner Research Institute is one of the largest pediatric research centers and consistently ranked among the top 10 for NIH funding among free-standing children’s hospitals in the United States. In addition, Nationwide Children’s Hospital has been consistently ranked on the US News & World Report’s “America’s Best Children’s Hospitals Honor Roll”. | | Potential candidates should send their CV (with publication list) to | | Mingtao Zhao, PhD | Principal Investigator | Center for Cardiovascular Research | Nationwide Children’s Hospital | Assistant Professor | Departments of Pediatrics | The Ohio State University | TEL: 614-355-6748 | Email: Mingtao.Zhao@nationwidechildrens.org

IGM Senior Research Associate - Rajappa lab

Requisition ID: 2023-47428
Overview: We are seeking a Senior Research Associate – Tumor Immunology The Rajappa Lab is accepting applications for a Post-Doctoral Scientist. Applicants should have either a PhD or MD from backgrounds in Neuroscience, Tumor Immunology or Cancer Biology. Backgrounds in Molecular, Cellular and Developmental Biology will also be considered. Experience with animal tumor modeling, cell sorting and flow cytometry is desired. Additional experience with Genomics/Bioinformatics/Statistics is a plus.

IGM Post Doctoral Scientist - Rajappa lab

Requisition ID: 2023-45740
Overview: Post Doctoral Scientist - IGM Rajappa Lab | | | Applicants should have either a PhD or MD from backgrounds in Neuroscience, Tumor Immunology or Cancer Biology. Backgrounds in Molecular, Cellular and Developmental Biology will also be considered. Experience with animal tumor modeling, cell sorting and flow cytometry is desired. Additional experience with Genomics/Bioinformatics/Statistics is a plus. | | Our vision aims to rapidly translate research discoveries into lasting treatment options for pediatric and young adult patients afflicted with Central Nervous System (CNS) tumors. Specifically, our laboratory is studying the mechanisms that potentiate low to high grade glioma progression. We use transgenic brain tumor mouse models that recapitulate low to high grade glioma progression and correlate our findings with peripheral blood and tumor specimens from patients with CNS tumors. These models also serve as a platform to explore the contribution of the tumor microenvironment and myeloid cells in low grade glioma progression and also test novel therapeutic agents aimed at impairing malignant transformation. To that end, we aim to develop next-generation therapies that modulate the innate immune myeloid cell rich glioma microenvironment. To dissect myeloid cell heterogeneity within gliomas, our lab leverages Next-Generation Sequencing in addition to Single-cell RNA sequencing to elucidate the functional role of these innate immune populations. | | Our long-term goals are to use these innovative tools in order to translate our findings into new age clinical trials for patients with gliomas and validate select myeloid cell populations as in-vivo biomarkers that may enhance risk stratification and targeted approaches for this patient population. | | Our team is part of the Institute for Genomic Medicine (IGM) at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, which is at the forefront of using genomic sequencing in the clinical setting to predict best health outcomes for patients and is one of the driving forces shaping precision medicine. Led by a team of internationally-renowned genomic medicine scientists (Richard Wilson, PhD and Elaine Mardis, PhD) IGM is housed in the campus’ newest research building, spanning ~25,000 square feet of laboratory and office space in a highly interactive setting. | | Please include “Translational Neuro-Oncology Research Scientist Position” in the subject line. Competitive applications will be evaluated when they are received and the position will remain open until the position is filled. | | The Research Scientist position will design and lead scientific aspects of a project, such as study design, grant proposal drafting, outcome evaluation, and manuscript writing etc. The candidate must have strong interpersonal skills and capable of working with technical staff to drive the projects forward. The candidate must be able to verbally and visually communicate clearly to all level of stakeholders. | | From the results of studies, helps to develop hypotheses for further investigation. With minimal guidance from the PI, prepares technical materials such as abstracts, annual reports, scientific papers, grants, and presentations. Publishes scientific articles in appropriate refereed journals.

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