Nationwide Children's Hospital

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Job Locations US-OH-Columbus
Requisition Post Information* : Posted Date 2 weeks ago(10/11/2021 8:17 AM)
Requisition ID
2021-31682
Overview
The Abigail Wexner Research Institute at Nationwide Children’s Hospital seeks an outstanding faculty candidate for recruitment at all ranks (tenure track assistant, associate or full professor). The individual should direct a research laboratory focused on pediatric cardiovascular disease and/or relevant basic science areas.  Scientific areas of particular interest and/or scientific expertise include the use of cardiac organoid and animal models, chemical biology/drug discovery, bioengineering and gene therapy for cardiovascular diseases. A track record of translational research is desired.
Job Locations US-OH-Columbus
Requisition Post Information* : Posted Date 1 month ago(9/15/2021 8:06 AM)
Requisition ID
2021-31217
Overview
Post Doctoral Scientist - Research Cardiovascular- Dr. Zhao's lab |   | A postdoctoral scientist position is immediately available in Dr. Mingtao Zhao’s laboratory in the Center for Cardiovascular Research at the Nationwide Children’s Hospital and The Ohio State University in Columbus, Ohio. The Zhao lab is using patient-derived induced pluripotent stem cells (iPSCs), CRISPR/Cas9 genome editing, and single-cell genomics to study the molecular and genetic mechanisms of cardiovascular development and congenital heart disease (PNAS 2017, PMID: 29203658; Circ Res 2017, PMID: 29030344; Stem Cells 2020, PMID: 32232889, Front Cell Dev Biol 2021, PMID: 33585486). The goal of the Zhao lab is to elucidate the cause-consequence relationship of a given genetic variant in regulatory elements (such as enhancers) in the contribution of cardiovascular disease using patient-specific iPSCs that retain all genetic information of the affected patients. The Zhao lab is currently funded by NIH/NHLBI, Additional Ventures, AHA and Abigail Wexner Research Institute at Nationwide Children’s Hospital. This is a great opportunity for young investigators who aim to establish an independent academic career in the next few years. Successful candidates should have a PhD/MD or equivalent degree (< 3 years after graduation) and should have solid expertise in cardiac physiology, cardiovascular development, or organoid biology. Candidates who have additional expertise in bioinformatics or CRISPR/Cas9 genome editing or tissue engineering would be preferred.The Center for Cardiovascular Research currently has a NIH-funded T32 postdoctoral program to provide interdisciplinary, translational, and state-of-the-art research training in congenital and acquired heart disease, partnered with The Ohio State University College of Medicine. The Abigail Wexner Research Institute is one of the largest pediatric research centers and consistently ranked among the top 10 for NIH funding among free-standing children’s hospitals in the United States. In addition, Nationwide Children’s Hospital has been consistently ranked on the US News & World Report’s “America’s Best Children’s Hospitals Honor Roll”. |   | Potential candidates should send their CV (with publication list) and Cover Letter describing future research vision to |   | Mingtao Zhao, PhD | Principal Investigator | Center for Cardiovascular Research | Nationwide Children’s Hospital | Assistant Professor | Departments of Pediatrics | The Ohio State University College of Medicine | Email: Mingtao.Zhao@nationwidechildrens.org |   | Schedule: (Full time, Benefits Eligible) |   | Location: | Research I I I700 Children's DrColumbus, Ohio 43205
Job Locations US-OH-Columbus
Requisition Post Information* : Posted Date 2 months ago(8/18/2021 3:44 PM)
Requisition ID
2021-30703
Overview
Post Doctoral Scientist - RI RM Stacy |   | A postdoctoral research position is available within the Center for Regenerative Medicine at Nationwide Children’s Hospital working with Dr. Mitchel Stacy. Research in the lab is focused on the development of non-invasive medical imaging techniques for evaluation and characterization of cardiovascular diseases and regenerative medicine scaffolds. Of particular interest is imaging of quantitative perfusion, vascular inflammation, and vascular remodeling. The lab utilizes multiple imaging modalities, which include SPECT/CT, PET/CT, CT angiography, ultrasound, and MRI. Experimental work and training will be focused on pre-clinical and clinical imaging of vascular diseases, tissue-engineered scaffolds, and diabetes, with particular emphasis on medical image processing methodology. Imaging research will be completed through collaborative efforts between The Research Institute at Nationwide Children’s Hospital and The Ohio State University College of Medicine. Candidates should be highly motivated with an interest in pre-clinical and/or clinical imaging. |   | Schedule: (Full time, Benefits Eligible) |   | Location: | Research I I I700 Children's DrColumbus, Ohio 43205
Job Locations US-OH-Columbus
Requisition Post Information* : Posted Date 4 months ago(7/7/2021 12:12 PM)
Requisition ID
2021-29923
Overview
Post Doctoral Scientist - Yr 1-3 Kerlin |   | An NIH-funded postdoctoral position is available in the Kerlin Research Laboratory within the Center for Clinical and Translational Research of the Abigail Wexner Research Institute at Nationwide Children’s Hospital. The NIH-funded project will focus on understanding coagulation signaling in glomerular cells via the Protease-Activated Receptor (PAR) family of GPCRs. Individuals with expertise in molecular and cellular biology who are interested in working with an interdisciplinary group to drive discovery of the mechanisms by which coagulation signaling drives chronic kidney disease progression are encouraged to apply. Experience in coagulation biochemistry, coagulation signaling, and/or kidney disease pathogenesis is desirable but not required. The work will center on the use of transgenic mouse models of kidney disease and coagulation signaling complemented by work in genetically manipulated cell culture models. Required skills include cloning, directed mutagenesis, cell culture transfection and expression, and protein expression and purification. |   | Recent discoveries from the Kerlin Laboratory strongly suggest that thrombin generated within the glomerulus drives progression of chronic kidney disease toward end-stage kidney disease (ESKD). ESKD is a leading cause of death and ESKD-related mortality is predominantly due to cardiovascular morbidity (e.g. myocardial infarction and stroke). Thus, the long-term goal of our research is to reveal key mechanistic interactions between the coagulation and kidney systems and identify novel molecular targets with potential to slow or halt kidney disease progression. |   | Post-Doctoral Scientists work under the mentorship of an established Abigail Wexner Research Institute (AWRI) Principal Investigator to design and conduct experiments in a specific area of research. From the results of studies, helps to develop hypotheses for further investigation. Prepares technical materials such as abstracts, annual reports, scientific manuscripts, and presentations. Publishes manuscripts in appropriate refereed journals. Works toward a goal of becoming independent in his/her research effort, and eventually obtaining external research funding. Appointment as a Post Doc is a maximum of 5 years in length. |   |   |   |   | Schedule: (Full time, Benefits Eligible) |   | Location: | Wexner Center | 700 Children's Dr | Columbus, Ohio 43205

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