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Post Doctoral Scientist - Gene Therapy/CRISPR/Stem Cell Biology

Requisition ID: 2024-50149
Overview: We are seeking a postdoctoral scholar for a position to join Dr. Sriram Vaidyanathan’s lab at Nationwide Children’s Hospital and The Ohio State University. Our lab is in the Center for Gene Therapy at Nationwide Children’s Hospital (NCH). The NCH Center for Gene Therapy has a long track record of training leaders in gene therapy, has been the site of the development of the first FDA-approved AAV-mediated gene therapy for neuromuscular disease (SMA). Our lab is focused on the development of genetic therapies for cystic fibrosis. | | The development of CRISPR/Cas9 over the past decade has enabled the development of precise genetic therapies for diseases such as sickle cell disease and thalassemia. The Vaidyanathan laboratory is investigating the use of CRISPR/Cas9 based genome editing to treat CF and other diseases affecting the lungs. This position presents the opportunity to further develop new CRISPR/Cas9 based gene editing methods, development of airway stem cell therapies, and study airway stem cell biology. | | With guidance from Dr. Vaidyanathan, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will include designing and performing experiments, mentoring students/technicians (if desired), analyzing and presenting your results and conclusions, generating figures, and writing and publishing manuscripts. A background in gene therapy, cystic fibrosis, single-cell analysis or airway stem cell research would be beneficial. The selected candidate must be professional, self-motivated, and dedicated, with strong communication and interpersonal skill sets that fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment. | | Visit our lab website for more information about our research: | https://www.nationwidechildrens.org/find-a-doctor/profiles/sriram-vaidyanathan

Regulatory Project Coordinator - Regulatory Affairs Administration

Requisition ID: 2024-50146
Overview: The Regulatory Project Coordinator coordinates the processing, reporting, and special projects for the Office of Research Regulatory Affairs. This position is responsible for maintaining relevant records through the database, and preparing reports on FDA-regulated clinical trial activity. This position is also responsible for interactions with external clients (project management, billing, etc.).

IGM Genetic Technologist I

Requisition ID: 2024-50144
Overview: IGM Genetic Technologist I/II/III- Next Generation SequencingOverview | Full-Time: Main Campus, Mon-Fri: Day Shift | | We are seeking a Genetic Technologist - This position is responsible for performing Next Generation Sequencing research assays including library preparation, genetic and genomic data analyses, quality control, operational improvement, and preventative maintenance within the Institute for Genomic Medicine Genomic Services Laboratory.

Research Assistant NE - Research Microbial- Bailey lab

Requisition ID: 2024-50141
Overview: Research Assistant – Brain-Gut Interactions Research | | | We are seeking a Research Assistant | A research position is available immediately for a Research Associate with experience in rodent models and basic behavioral neuroscience techniques (e.g., tests of cognitive or emotional behaviors, immunohistochemistry, immunofluorescence, brain cell isolation and gene expression analyses). Dr. Michael Bailey is investigating mechanisms by which gut microbes and mucosal immune responses impact brain development after devastating pediatric diseases and conditions, including necrotizing enterocolitis or exposure to stress in utero. |

IGM - Bioinformatics Software Developer - ODS

Requisition ID: 2024-50124
Overview: IGM Bioinformatics Software Developer I | | | Overview | | Full-time: Main Campus/Remote/Hybrid, Mon-Fri | | We are looking for a candidate who can work closely with faculty and staff to design and build efficient instrument-to-interpretation pipelines for next-generation sequencing (NGS) workflows, optimizing outcomes for our genomic medicine initiatives. It is expected that the individual in this position will possess strong software development abilities, enjoys solving complex problems and has a desire to make an impact in medical research and patient care. The candidate will also be encouraged to participate in bioinformatics related discussions, group meetings and presentations for the Institute for Genomic Medicine (IGM).

IGM Bioinformatics Analyst I

Requisition ID: 2024-50115
Overview: IGM Bioinformatics Analyst I | | We are looking for a candidate that will assist in all aspects of next-generation sequencing analysis including data generation, analysis, interpretation, and publication. This entry-level position involves maintaining, running, and troubleshooting genomic pipelines for next-generation sequencing assays in clinical, translational and research settings. The ideal candidate will possess strong data processing and data quality control abilities, enjoy solving complex problems and have a desire to make an impact in medical care through advancing our understanding of the role of the human genome in disease. The candidate will also be encouraged to participate in bioinformatics related discussions, group meetings and presentations for the Institute for Genomic Medicine (IGM). Previous experience in bioinformatics or a computational biological background is preferred but not required for this position.

Research Faculty Transition & Integration Coordinator

Requisition ID: 2024-50111
Overview: The Research Faculty Transition and Integration Coordinator is responsible for executing research-based faculty onboarding, integration, and off-boarding activities. Provides an assortment of concierge services to new faculty members including move coordination, equipment management, lab planning, recruiting staff, assisting with IRB/IACUC/IBC protocol development and submission, and ensures faculty member is familiar with available resources at NCH. This position implements strategies to accelerate time to productivity and improves the faculty experience by ensuring smooth and seamless transitions. The Research Faculty Transition and Integration Coordinator will identify and recommends new program initiatives and interventions to enhance the effectiveness of activities.

Scientific Writer Sr.

Requisition ID: 2024-50110
Overview: Sr. Scientific Writer- CONNECT | CONNECT is an international collaborative network of pediatric cancer centers with the objective to improve outcomes for children with newly diagnosed and recurrent/progressive high-risk brain tumors The Operations center for this network is located at Nationwide Children’s Hospital in Columbus, OH. | | | CONNECT conducts small, scientifically rational, pilot studies to assess feasibility and early efficacy of incorporating promising new therapies into established frontline therapeutic regimens. CONNECT works alongside phase I consortia and large clinical trial groups to target high-risk pediatric and young adult tumors.

Research Intern- RI Childhood Cancer Research Cripe

Requisition ID: 2024-50082
Overview: Provides assistance in research experiments under direction of Research Assistant; obtains supplies and equipment needed for research projects; maintains laboratory records.

Veterinary Technician - Animal Resource Core

Requisition ID: 2024-50074
Overview: Veterinary Technician - Animal Resource Core | | General Description: Assist veterinarian, veterinary team lead and senior veterinary technician in providing veterinary care for a variety of laboratory animal species and technical support for research protocols.

Associate Director - Research- ARC

Requisition ID: 2024-50059
Overview: This position is multifaceted involving administrative, regulatory, and veterinary activities. This position develops and manages the clinical and technical veterinary program, including the aquatics program. In addition, provides clinical oversight/support for research animal care and use, medicine, disease, diagnosis, and experimental techniques for researchers at the Abigail Wexner Research Institute. Ensures research and clinical activities adhere to the United States Department of Agriculture (USDA), Public Health Service (PHS), and AAALAC rules and regulations. In the event the Director/Attending Veterinarian is absent, the Associate Director will assume all responsibilities to lead the department.

Research Associate - Center for Gene Therapy- Wein

Requisition ID: 2024-50052
Overview: The Wein Lab is focusing on Neuromuscular Disorders such as Duchenne Muscular dystrophy, which is a devastating disease leading to death of patients at age 20-30 years. Our lab developed an expertise in translational research, an emerging field which can be summarized as understanding the cause of a disease and learning from it in order to develop innovative therapeutic strategies. We are fully committed to continuing to integrate basic science and gene therapy skills in order to advance understanding and treatment of the muscular dystrophies. Our lab’s long term projects focus on RNA and DNA editing and gene transfer as therapies for neuromuscular disorders, as well as furthering fundamental research on muscle function. In particular, our lab uses the most recent technologies such as virus-mediated exon-skipping and the CRISPR/Cas9 genome editing tool. | We are looking for a highly motivated research associate who is energetic and intelligent to join our dynamic team. In particular, we are looking for someone with expertise in molecular biology (qPCR, IF, WB), as well as handling mouse colonies, mouse injection and dissection experiences to collect all muscles and peripheral organs. Experience in mounting muscle tissue is preferred. No background in gene therapy is required, however the candidate should have a high interest in human genetics and diseases and should be eager to learn and work on the bench in an independent manner. Finally, our team relies on good teamwork and therefore, the candidate should be a good communicator and team player. The job description includes, but is not restricted to performing research experiments, maintaining records of experiments, preparing laboratory reports, analyzing data and preparing publications and grants applications.

IGM Chief Research Associate- Neurosurgery

Requisition ID: 2024-50043
Overview: Manages daily operations in the lab, supervises and trains staff on procedures, and ensures that the standard operation procedures and quality control program is compliant. Provides on-call coverage for section on rotating basis on holidays and weekends.

IGM Medical Laboratory Assistant- IGM

Requisition ID: 2024-49985
Overview: IGM Medical Lab Assistant | | We are seeking an IGM Medical Laboratory Assistant to join our team. The Medical Lab Assistant is responsible for clerical and patient care support tasks which enable technologists to complete testing of patient specimens in a timely manner.

Research Intern- RI Vaccines & Immunity Peeples

Requisition ID: 2024-49969
Overview: Provides assistance in research experiments under direction of Research Assistant; obtains supplies and equipment needed for research projects; maintains laboratory records.

Clinical Research Coordinator I - RI Biobehavioral Nelson

Requisition ID: 2024-49960
Overview: A full-time Clinical Research Coordinator is being recruited for a collaborative research team investigating the relationship between brain development and mental wellbeing in youth. The successful candidate will contribute multiple ongoing studies examining the neuroanatomical and functional substrates that contribute to cognitive, social and emotional functioning in both medical populations and healthy youth. Duties will involve direct work with research participants (recruitment, in-person data collection), including helping to execute study visits involving magnetic resonance imaging (MRI), neurocognitive assessment, data management, statistical analyses, and dissemination of research results. Data management will include scoring standardized assessments, medical record reviews, data entry and verification, and training in the processing of neuroimaging data. This position will involve close collaboration with the principal investigator, as well as other research staff and investigators at NCH and medical staff at NCH/The Ohio State University. Opportunities exist for mentorship and professional development for applicants who are interested in gaining experience that will prepare them to apply for advanced graduate programs, particularly in clinical psychology, neuropsychology, or neuroscience. In addition to mentorship provided by the lab principal investigator, lab members have the option to participate in the Center for Biobehavioral Health Post-Baccalaureate Program, which is dedicated to aiding staff in identifying and understanding career paths and managing the application process for various fields’ graduate programs. Applicants are encouraged to submit resumes with sufficient detail to demonstrate their academic record (i.e., college GPA) and relevant research or work experience. Cover letters are encouraged.

Research Associate Sr.- Center for Gene Therapy - Harper

Requisition ID: 2024-49957
Overview: Senior Research Associate in Gene Therapy | | Employer: Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children’s Hospital | | Location: Columbus, Ohio, USA | | Salary: Competitive salary based on the candidate’s experience, benefits include family health insurance, matched retirement account | | Discipline: Life Sciences, Gene Therapy, Cellular and Molecular Biology, RNAi, CRISPR, Neurological diseases, Peripheral Neuropathy, neuromuscular diseases, Adeno-Associated Viral (AAV) vectors, Immunology, | | Start Date: As soon as possible | | Position Type: Full-time | | Organization Type: Non-profit | | The Harper Lab at the Center for Gene Therapy at Nationwide Children’s Hospital (NCH) is focused on developing gene therapies for muscular dystrophies and neuropathies. We are seeking a highly motivated, experienced, and independent Senior Research Associate to join our energetic, diverse and innovative team. We do molecular, cellular, and in vivo work. The ideal candidate will have experience in molecular biology and biochemistry (e.g. molecular cloning, western bloting, qPCR, various in vitro assays, and cell culture), as well as show talent or promise in scientific writing. Pre-clinical work in animal models may also be needed. This person will develop and validate new protocols for in vitro and in vivo experiments and will be responsible for training and directing junior lab members. A strong candidate will also have outstanding organization skills. | | The Harper Lab operates as a team and we promote and esprits de corps and work-life balance. Our philosophy centers on the notion that productivity is more important than time spent in the lab, and although we seek an individual capable of working on-site daily, we are open to flexible working hours. | | This position includes excellent retirement and health insurance benefits.

ODS Data Sciences Strategy & Applications Lead

Requisition ID: 2024-49955
Overview: The Lead, Data Sciences Strategy and Applications, occupies a vital leadership position within the Office of Data Sciences at the Abigail Wexner Research Institute. This role demands a visionary leader with extensive experience in software development for data sciences applications, focusing on bioinformatics, computational genomics, data visualization, and leveraging big data in biomedical health sciences research. The successful candidate will lead a team in developing sophisticated data solutions that incorporate machine learning, advanced language models, statistical analysis, and data visualization techniques to address the complex challenges of biomedical data science.

Post Doctoral Scientist Yr 1-3 - IGM Bedrosian

Requisition ID: 2024-49950
Overview: The Bedrosian lab in the Institute for Genomic Medicine is seeking a post-doctoral scientist to join our team. Our translational research group focuses on studying the genetics of epilepsy and other neurodevelopmental diseases using patient-derived tissue as well as murine models. We use cutting-edge techniques including single cell RNA-sequencing, spatial transcriptomics/proteomics, and other genomic techniques. The successful candidate will be engaged in projects exploring the molecular etiology of epilepsies through bioinformatic analysis of single-cell sequencing data and other genomic data. Prior experience with R and Seurat is preferred. The Institute for Genomic Medicine provides a stellar training environment with exposure to world-class expertise in genomics. We are a collaborative group with opportunities to build new skillsets and interact across the institute. Post-doctoral scientist will report to PI.

Research Purchasing Coordinator

Requisition ID: 2024-49935
Overview: The Purchasing Coordinator works under the supervision of the Purchasing Manager and is responsible for maintaining the efficient flow of purchase order requisitions and assisting with the placing of routine orders. This position works closely with internal customers to resolve order issues and supply interruptions. This position additionally works with Supply Chain staff to address supply concerns and update the SCIS system.

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