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IGM Post Doctoral Scientist - Rajappa

Requisition ID: 2023-44391
Overview: Post Doctoral Scientist - IGM Rajappa Lab | | | Applicants should have either a PhD or MD from backgrounds in Neuroscience, Tumor Immunology or Cancer Biology. Backgrounds in Molecular, Cellular and Developmental Biology will also be considered. Experience with animal tumor modeling, cell sorting and flow cytometry is desired. Additional experience with Genomics/Bioinformatics/Statistics is a plus. | | Our vision aims to rapidly translate research discoveries into lasting treatment options for pediatric and young adult patients afflicted with Central Nervous System (CNS) tumors. Specifically, our laboratory is studying the mechanisms that potentiate low to high grade glioma progression. We use transgenic brain tumor mouse models that recapitulate low to high grade glioma progression and correlate our findings with peripheral blood and tumor specimens from patients with CNS tumors. These models also serve as a platform to explore the contribution of the tumor microenvironment and myeloid cells in low grade glioma progression and also test novel therapeutic agents aimed at impairing malignant transformation. To that end, we aim to develop next-generation therapies that modulate the innate immune myeloid cell rich glioma microenvironment. To dissect myeloid cell heterogeneity within gliomas, our lab leverages Next-Generation Sequencing in addition to Single-cell RNA sequencing to elucidate the functional role of these innate immune populations. | | Our long-term goals are to use these innovative tools in order to translate our findings into new age clinical trials for patients with gliomas and validate select myeloid cell populations as in-vivo biomarkers that may enhance risk stratification and targeted approaches for this patient population. | | Our team is part of the Institute for Genomic Medicine (IGM) at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, which is at the forefront of using genomic sequencing in the clinical setting to predict best health outcomes for patients and is one of the driving forces shaping precision medicine. Led by a team of internationally-renowned genomic medicine scientists (Richard Wilson, PhD and Elaine Mardis, PhD) IGM is housed in the campus’ newest research building, spanning ~25,000 square feet of laboratory and office space in a highly interactive setting. | | Please include “Translational Neuro-Oncology Research Scientist Position” in the subject line. Competitive applications will be evaluated when they are received and the position will remain open until the position is filled. | | The Research Scientist position will design and lead scientific aspects of a project, such as study design, grant proposal drafting, outcome evaluation, and manuscript writing etc. The candidate must have strong interpersonal skills and capable of working with technical staff to drive the projects forward. The candidate must be able to verbally and visually communicate clearly to all level of stakeholders. | | From the results of studies, helps to develop hypotheses for further investigation. With minimal guidance from the PI, prepares technical materials such as abstracts, annual reports, scientific papers, grants, and presentations. Publishes scientific articles in appropriate refereed journals. | | | https://youtu.be/lFpdclN_hAw | |

Post Doctoral Scientist - Cancer Biology/Epigenetics/Developmental Biology

Requisition ID: 2023-44121
Overview: We are seeking a postdoctoral scholar to join Dr. Genevieve Kendall’s lab at Nationwide Children’s Hospital and The Ohio State University. Our team is focused on developing basic and translational models of pediatric muscle cancer, which are devastating and aggressive solid tumors with limited therapeutic options. We use cell culture, mouse models, and transgenic zebrafish to understand the conserved biology of the disease and then apply that knowledge to identify therapeutic targets. | | With guidance from Dr. Kendall, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will include performing experiments, determining the next steps, developing and implementing new and existing protocols, analyzing and presenting your results and conclusions, generating figures, and writing and publishing manuscripts. A background in cancer biology and/or genomics would be beneficial. Previous experience working with zebrafish is not required. The selected candidate must be professional, self-motivated and dedicated, with strong communication and interpersonal skill sets that fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment. | | Visit our lab website for more information about our research and team: https://www.nationwidechildrens.org/research/areas-of-research/center-for-childhood-cancer-and-blood-diseases/kendall-lab

Clinical Research Coordinator Team Lead - Research Injury Leonard

Requisition ID: 2023-44032
Overview: Clinical Research Coordinator Team Lead - Research Injury Leonard | | The Leonard Lab Team Lead will help oversee all research projects within the lab. The Team Lead will serve as a liaison internally between collaborators within the Abigail Wexner Research Institute at Nationwide Children’s Hospital (RINCH)and within clinical services at Nationwide Children’s Hospital. Externally, the Team Lead will work closely with our HRSA funded projects that include the Great Lakes Emergency Medical Services (EMS) for Children’s Research Node (GLEMSCRN) within the Pediatric Emergency Care Applied Research Network (PECARN), the EMS for Children Ohio state partnership grant and the EMS for Children Innovation and Improvement Center. The Team Lead will also be responsible for external NIH-funded collaborations related to trauma and EMS research.

LPN - Chillicothe Pediatrics

Requisition ID: 2023-44016
Overview: This is a part-time, benefits eligible position, working Monday-Friday between 8:00 a.m. and 5:00 p.m. | | Provides technical nursing care to acute and chronically ill children from the age of birth to 21 years and selected adults patients, under the direction of a RN Care Manager, and in accordance with the Ohio Board of Nursing Law and Rule. (Sections 4723-4-01, Ohio Administrative Code or OAC, 4723-4-04, OAC, 4723-4-06, OAC, and 4723-4-08 OAC). Demonstrates competence defined (*) in LPN II responsibilities in providing age appropriate care and service to pediatric patients from birth to 21 years, and selected adults.

BPC Inventory & Banking Manager

Requisition ID: 2023-43739
Overview: -The Biopathology Center (BPC) within The Research Institute at Nationwide Children’s Hospital (TRINCH)is a biorepository with the primary objective of long-term acquisition, storage, and distribution of a large number of cancer, normal, and diseased biospecimens obtained following proper regulatory guidelines, and related data for the purpose of supporting cutting edge research. The BPC Inventory and Banking Manager is responsible for the development, coordination, and supervision of the daily operational activities of technical and professional employees engaged in conducting all tissue processing, banking and distribution activities of the BPC; these include activities related, but not limited, to the Children’s Oncology Group (COG), NRG Oncology (formerly Gynecologic Oncology Group), SWOG, institutional research projects, and the Pediatric Division of the Collaborative Human Tissue Network (CHTN). This position will frequently interact with Leadership, as well as external investigators and organizations, including the key members of the various sponsor groups. The BPC Inventory and Banking Manager is also responsible for coordination and execution of activities to assist with ongoing BPC project development, lending to process improvement. In addition, the position assists with strategic planning activities, budget forecasting, group facilitation and other staff functions.

Research Assistant - RI Cancer Biology/Brain Tumor

Requisition ID: 2023-43703
Overview: Performs research experiments, plan and independently execute specialized laboratory research. To make accurate observations, to record test results, to analyze data, and to develop new methods. To guide the efforts of other laboratory personnel by explaining laboratory techniques and assisting in their experiments in accordance with provisions of the approved protocol; maintains records of experiments and prepares laboratory reports; assists in analyzing data and preparing publications.

IGM Bioinformatics Scientist - RI Miller

Requisition ID: 2023-43693
Overview: The Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital is creating a future that integrates genomics into the everyday practice of pediatrics. Led by a team of internationally renowned genomic medicine scientists, the IGM is housed in the campus’ newest research building, spanning ~25,000 square feet of laboratory and office space in a highly interactive setting.We are looking for a Bioinformatics Scientist to join our Research Group to study single-cell transcriptomics of various pediatric diseases. Our projects span multiple interest areas, including cancer biology, epilepsy, and infectious disease research. We have multiple translational research protocols, from which we are actively generating single-cell RNA-sequencing data from patient specimens. The ideal candidate will be expected to develop hypotheses in collaboration with the research team, perform analysis of existing data to test hypotheses, implement new analysis strategies on a project-specific basis, generate graphs and figures, share their findings with the research team, and assist in the preparation of manuscripts. Candidates should have prior experience working with single-cell RNA-seq datasets as well as proficiency in R. This is an exciting opportunity in a translational research setting, with opportunities to work on a diverse spectrum of projects which may have a direct impact on pediatric patient care. Excellent verbal and written communication skills will be essential as the individual will work collaboratively with bioinformaticians, biologists, research professors, and clinicians on projects that lead to publications and presentations at professional meetings.

Research Associate - Research Childhood Cancer - Stanton lab

Requisition ID: 2023-43659
Overview: Conducts independent research within a general area decided upon in conjunction with a Principal Investigator; prepares position papers and research reports; assists in the preparation of scientific publications and research grant proposals; prepares budget proposals for conducting research studies.

Post Doctoral Scientist - Cancer Biology/Immunotherapy

Requisition ID: 2023-43615
Overview: Dr. Long-Sheng Chang Lab | | A postdoctoral position is available in the Chang Research Laboratory within the Center for Childhood Cancer Research of the Abigail Wexner Research Institute at Nationwide Children’s Hospital. This project will focus on developing novel medical therapies, including targeted therapies and immunotherapies, for the treatment of neurofibromatosis type 2 (NF2)- and neurofibromatosis type 1 (NF1)-associated tumors and pediatric soft-tissue and bone sarcomas. Individuals with experience in or willingness to learn tumor biology and signaling, multi-omics analysis, systems biology, and therapeutic testing, as well as expertise in molecular and cellular biology and animal models are encouraged to apply. | | Neurofibromatosis (NF) is a group of genetic diseases that predispose individuals to the development of multiple tumors of the nervous systems and other soft tissues, as well as other debilitating manifestations. Due to limited treatment options, these NF-associated tumors caused significant morbidity and mortality. To develop a medical therapy for NF-associated tumors, our lab has studied the NF2 tumor-suppressor gene function and expression during development and tumorigenesis, and we have identified novel NF2 functions and potential druggable targets. Several cell culture and animal models for NF2-associated schwannomas and meningiomas and NF1-related malignant peripheral nerve sheath tumors (MPNSTs) have been generated and used to identify novel targeted drugs or drug combinations that potently suppress tumor growth. Several targeted compounds that my lab has studied have advanced into clinical trials. In addition, we have identified several natural protein translation inhibitors that potently suppress the growth of NF-associated tumors and multiple types of sarcomas. The ultimate goal of our research is to develop efficacious medical treatments for NF-associated tumors and sarcomas, ultimately leading to substantial improvement of clinical care and long-term treatment outcomes for these patients | | Post-Doctoral Scientists work under the mentorship of an established Abigail Wexner Research Institute (AWRI) Principal Investigator to design and conduct experiments in a specific area of research. From the results of studies, helps to develop hypotheses for further investigation. Prepares technical materials such as abstracts, annual reports, scientific manuscripts, and presentations. Publishes manuscripts in appropriate refereed journals. Works toward a goal of becoming independent in his/her research effort, and eventually obtaining external research funding. The position is renewable upon satisfactory annual evaluation.

Research Assistant - RI Childhood Cancer Chang

Requisition ID: 2023-43612
Overview: The qualified individual with a bachelor degree in biochemistry, molecular biology, or related discipline will perform research experiments to study the disease mechanisms of nervous system tumors and evaluate potential therapeutics, assist in analyzing data, prepare and maintain laboratory reports, and assist in preparing publications.

Post Doctoral Scientist - Cancer Biology/Epigenetics/Chromatin

Requisition ID: 2023-43417
Overview: We are seeking a Post-Doctoral Scientist - Dr. Benjamin Stanton’s Lab in the Center for Childhood Cancer @ The Abigail Wexner Research Institute at Nationwide Children’s Hospital is recruiting for postdoc positions. The candidates will be focusing on projects studying chromatin regulation in childhood cancers. The training environment will be highly collaborative, at the intersection of cancer biology, genomics, and epigenetics. Independence, motivation, and ability to formulate hypothesis-driven experiments will be important. For more information please reach out to Benjamin.Stanton@NationwideChildrens.org | | Research Profile: | Benjamin Stanton (nationwidechildrens.org)

Post Doctoral Scientist - Cancer Biology/Cell Cycle

Requisition ID: 2023-43344
Overview: Dr. Ruoning Wang Lab | | Description of Position: | Post-Doctoral Researcher Fellow positions are available in the Center for Childhood Cancer and Blood Diseases at The Abigail Wexner Research Institute at Nationwide Children Hospital-Ohio State University Comprehensive Cancer Center. The laboratory focuses on Cell Cycle and Cell Metabolism and is interested in: | 1) Establishing a framework for understanding the metabolic checkpoint. | 2) Delineating the metabolic landscape of tumor microenvironment. | 3) Developing novel therapies to treat cancer and autoimmunity. | | | Lab webpages: | https://www.nationwidechildrens.org/research/areas-of-research/center-for-childhood-cancer-and-blood-diseases/wang-lab | | | Qualifications: | - PhD. (or pending) in Molecular/Cellular Biology, Biochemistry or Cancer biology; | - Expertise in cell cycle and/or metabolism and/or genetically engineered mouse tumor models. | | Application Instructions: | To be considered for this position, please highlight your research background, expertise, and publications in the inquiry email and attach a CV (SINGLE PDF) with references’ contact to ruoning.wang@nationwidechildrens.org.

LPN - Mercy Health Village Sq Peds (Toledo)

Requisition ID: 2023-43271
Overview: Full time, benefits eligible. Monday-Friday. | | Provides technical nursing care to acute and chronically ill children from the age of birth to 21 years and selected adults patients, under the direction of a RN Care Manager, and in accordance with the Ohio Board of Nursing Law and Rule. (Sections 4723-4-01, Ohio Administrative Code or OAC, 4723-4-04, OAC, 4723-4-06, OAC, and 4723-4-08 OAC). Demonstrates competence defined (*) in LPN II responsibilities in providing age appropriate care and service to pediatric patients from birth to 21 years, and selected adults.

Research Associate - Research Childhood Cancer - Lee

Requisition ID: 2023-43246
Overview: Research Associate - Research Childhood Cancer - Lee | | Conducts independent research within a general area decided upon in conjunction with a Principal Investigator; prepares position papers and research reports; assists in the preparation of scientific publications and research grant proposals; prepares budget proposals for conducting research studies. The Research Associate is responsible for supporting the laboratory’s translational and basic research in the use of immune cells for cancer therapy and NK cell biology. Applicant should have expertise in basic cell and/or molecular biology laboratory techniques.

Post Doctoral Scientist - Translational Neuroscience/Viral Gene Therapy

Requisition ID: 2023-43214
Overview: Dr. Stephen Kaler Lab | | We are seeking Post-Doctoral Fellows to participate in translational neuroscience and viral gene therapyresearch- The Kaler Laboratory is committed to dissecting mechanisms and pathophysiology of inherited copper transport and other neurometabolic disorders and using the knowledge to improve health through rational remedies, including gene therapy. Patients and families affected by these conditions provide the impetus for scientific inquiry in the laboratory. | | To learn more about the Kaler Lab, refer to this link: | Stephen G. Kaler (nationwidechildrens.org) | | The Post-Doctoral Scientist will participate in focused research investigations on these topics: | - Viral Gene Therapy | - Motor Neuron Biology | - Human Copper Transport | - Copper and Cancer | In addition to molecular genetics, the Laboratory employs model organisms, cell biological and biochemical approaches, and conducts clinical protocols. Adeno-associated virus (AAV)-mediated gene therapy for Menkes disease, choroid plexus–targeted gene therapy for Alpha-mannosidosis, studies of motor neuron degeneration mediated by p97/valosin-containing protein (p97/VCP), mechanisms underlying other genetic disorders of copper transport, and the role(s) of copper in certain malignancies represent our diverse current directions. | | We are seeking highly motivated postdoctoral researchers who are energetic, have strong communication and interpersonal skills, and are interested in clinical/translational applications. Persons with broad experience in molecular and cellular biology, tissue culture, mouse husbandry and injection/dissection, zebrafish modeling of disease, or with clinical training (e.g., MD) are preferred. | | With careful mentorship, you will become responsible for leading independent projects that address the Laboratory’s overarching aims and align with your career goals. The positions involve, but are not restricted to: performing research experiments, maintaining records of experiments, preparing laboratory reports, analyzing data, preparing papers and grant applications, and attending/presenting at national and international meetings.

Research Assistant - Research Childhood Cancer

Requisition ID: 2023-43119
Overview: Research Assitant - Research Childhood Cancer | | Performs research experiments and clinical studies in accordance with provisions of the approved protocol; maintains records of experiments and prepares laboratory reports; assists in analyzing data and preparing publications. The Research Assistant is responsible for supporting the laboratory’s translational and basic research in the use of immune cells for cancer therapy and NK cell biology. Applicant should have experience in some basic cell and/or molecular biology laboratory techniques.

Ambulatory LPN Float - Mercy Spring Valley (Toledo)

Requisition ID: 2023-42617
Overview: | Provides technical nursing care to acute and chronically ill children from the age of birth to 21 years and selected adults patients, under the direction of a RN Care Manager, and in accordance with the Ohio Board of Nursing Law and Rule. (Sections 4723-4-01, Ohio Administrative Code or OAC, 4723-4-04, OAC, 4723-4-06, OAC, and 4723-4-08 OAC). Demonstrates competence defined (*) in LPN II responsibilities in providing age appropriate care and service to pediatric patients from birth to 21 years, and selected adults.

IGM Director Clinical Laboratory- Research

Requisition ID: 2023-42598
Overview: We are seeking a Clinical Laboratory Director - The Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital combines diagnostics, research genomics and clinical genetics professionals into an aligned center focused on integrating genomics into patient care. The IGM Clinical Laboratory performs integrated clinical genomic, molecular, microarray, FISH and cytogenetic analyses to diagnose a broad range of inherited diseases and cancer. | | The IGM clinical laboratory also serves as the testing reference laboratory for the Acute Lymphoblastic Leukemia, Wilms tumor, and Neuroblastoma disease disciplines within Children's Oncology Group (COG), performing molecular and cytogenetic analyses for clinical trial patients. Furthermore, the laboratory plays an integral role in the Molecular Characterization Initiative, part of the National Cancer Institute’s Childhood Cancer Data Initiative, to provide advanced genomic testing to a pediatric and adolescent population with cancer. | | The IGM clinical laboratory supports an ACGME-accredited fellowship in Laboratory Genetics and Genomics. The mission of this fellowship is to develop post-doctoral clinicians and scholars in serving pediatric and adult populations through the provision of expert clinical laboratory care. This mission directly aligns with the hospital and institutional strategic plan to integrate and grow genomic medicine across the enterprise. | | We emphasize collaborative interactions between clinicians, physician-scientists and basic science investigators to quickly transition cutting-edge research results into advanced diagnostics using state-of-the-art technology platforms. With world-renowned experts at the helm, we are moving genome-based testing into the mainstream of pediatric diagnosis and treatment by offering comprehensive next-generation sequencing for constitutional disorders and cancer diagnoses, making results accessible and meaningful for physicians and families. | | Schedule: (Full time, Benefits Eligible) | | Location: | Research III | 700 Children's Dr | Columbus, Ohio 43205

LPN - PediatriCare Associates

Requisition ID: 2023-42223
Overview: Monday - Friday, day shift working 4, 9 hour shifts a week 8a-6p | Part-time, benefits eligible. | | Provides technical nursing care to acute and chronically ill children from the age of birth to 21 years and selected adults patients, under the direction of a RN Care Manager, and in accordance with the Ohio Board of Nursing Law and Rule. (Sections 4723-4-01, Ohio Administrative Code or OAC, 4723-4-04, OAC, 4723-4-06, OAC, and 4723-4-08 OAC). Demonstrates competence defined (*) in LPN II responsibilities in providing age appropriate care and service to pediatric patients from birth to 21 years, and selected adults.

Faculty Position - Cell Therapy and Cancer Immunology

Requisition ID: 2022-40944
Overview: The Cell Therapy and Cancer Immunology program in the Abigail Wexner Research Institute at Nationwide Children's Hospital is expanding its faculty. The mission of the CTCI program is to bring novel cellular therapies to children and young adults with cancer or other inherited or acquired conditions (e.g., hematopoietic, infectious, immunologic, etc) through scientific discovery, cellular and genetic engineering, and efficient manufacturing for rapid translation to the clinic. More information is available at the link below: | | Cell Therapy and Cancer Immunology Program | | About the Faculty Position | - Seeking applicants at the Assistant, Associate, or Full Professor level with an independent laboratory research program focused on cellular therapy and/or related immunobiology | - Tenure-track faculty appointment in Department of Pediatrics, The Ohio State University | - Broad collaborative research potential throughout the Abigail Wexner Research Institute | - Consideration of joint positions in Centers for Vaccines and Immunity, Childhood Cancer, or Gene Therapy | Qualifications Required | - MD, MD/PhD, or PhD | - Track record of grant funding | - Track record of high quality first- or senior-author research publications relevant to cell-based therapies | About the CTCI Program | - Rapid growth- developed over 30 IND applications, 15 investigator-initiated cell therapy trials, 10 investigational cell therapy products, and over 60 patients treated with cellular therapy in 5 years | - Program integration with OSUCCC and the Pelotonia Institute for Immuno-Oncology | - CTCI infrastructure supports clinical trial development, IND preparation and submission, and GMP development/manufacturing of clinical-grade therapeutics | - Central manufacturing of investigation products for multi-institutional trials | | About the Research Institute: | - Top ten among free-standing children’s hospitals for NIH funding | - Designed for collaboration, creativity, and team science | - Comprehensive resources including regulatory support, tech transfer, genomics, and GMP facility | - 20 investigators hired in 2022 | - Nearly 200 investigators total | About Nationwide Children's Hospital: | - Among largest pediatric hospitals in the US: 1M+ patient visits annually | - Nationally recognized for diversity and inclusion | - US News & World Report Honor Roll hospital | - 1500+ total medical faculty | About Columbus, Ohio: | - State capital with 2M+ population | - Forbes #1 rising city for startups | - Outstanding quality of life and cost of living | Through our diversity, we achieve the highest standards of inclusiveness and create a culture that respects individual differences. It is the cornerstone of our strategic plan and how we attract the best people to ensure the best programs. To build a diverse workforce, Nationwide Children’s encourages applications from individuals with disabilities, minorities, veterans, and women. EEO/AA employer. | | Send correspondence, including curriculum vitae, a brief statement of research interests, and contact information for three references to Patrick.Kennedy@nationwidechildrens.org in Faculty Recruitment

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