The development of CRISPR/Cas9 over the past decade has enabled the development of precise genetic and stem cell therapies for treating many diseases. However, there are several hurdles in applying this technology to treat diseases affecting the lungs. The Vaidyanathan laboratory is investigating the use of CRISPR/Cas9 based genome editing to treat diseases affecting the lungs, starting with cystic fibrosis (CF). The focus of this project is to develop an airway stem cell therapy for treating cystic fibrosis (CF). This would be a great opportunity to gain experience in genome editing, stem cell biology and tissue engineering. Our lab is in the Center for Gene Therapy at Nationwide Children’s Hospital (NCH). The NCH Center for Gene Therapy has a long track record of training leaders in gene therapy, has been the site of the development of the first FDA-approved AAV-mediated gene therapy for neuromuscular disease (SMA). Our lab is looking for a Research Assistant to join our energetic and innovative team to carry this mission forward. The individual will work full-time, under the guidance of the PI, Dr. Sriram Vaidyanathan. The position will involve molecular biology, cell culture, working with mice (after sufficient training) and some lab support tasks such as ordering supplies and equipment, maintaining lab records, and adhering to safety regulations . The individual will perform experiments supporting isolation of cells from airway tissue, molecular biology, cell culture of airway stem cells, differentiation of airway stem cells in air-liquid interface and animal work. They may be expected to troubleshoot existing protocols, develop novel protocols and provide technical and scientific advice to other research personnel in lab. The individual will acquire other career development opportunities, such as presenting at lab meetings, participating in journal clubs, and the possibility of authorship on publications that will arise from their work.
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The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individual so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under his/her supervision. EOE M/F/Disability/Vet
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