Nationwide Children's Hospital

Post Doctoral Scientist - Gene Therapy

Posted Date 6 months ago(12/23/2021 8:52 AM)
Requisition ID
2021-33149
Category
Research

Overview

We are seeking a Post-Doctoral Scientist - The Bradbury Laboratory is dedicated to understanding disease mechanisms and developing therapeutic approaches for rare, pediatric neurodegenerative disorders. Advances in adeno-associated virus (AAV) vectors have led to safer and more efficient viral vehicles to deliver therapeutic transgenes in a single injection, and gene therapy is now a favorable therapeutic intervention for monogenic diseases.

 

A primary focus of the Bradbury lab is improving AAV targeting of myelinating cells, a current limitation of AAV, in order to advance therapeutic outcomes for leukodystrophies, other white matter disorders, and diseases of the peripheral nervous system. The Bradbury lab is translational in nature with a commitment to safely and efficiently moving therapies into the clinic for rare, pediatric disorders.

  

We are looking for a highly motivated postdoctoral person to join our dynamic team. In particular, we are looking for someone with experience in molecular biology (cloning, qPCR, IF, WB), as well as mouse experience (breeding, behavioral testing, injections, and dissection). Background in gene therapy and/or neuroscience is preferred but not required. The applicant should be highly interested in translating therapies for pediatric genetic diseases and should be eager to learn and work on the bench in an independent manner.

 

Investigator       Allison Bradbury, Ph.D.

Principal Investigator, Center for Gene Therapy, NCH

Assistant Professor, Department of Pediatrics, OSU

Nationwide Children’s Hospital

700 N. Children’s Drive

Columbus, Ohio  43205

                     

Contact:            allison.bradbury@nationwidechildrens.org

614-355-2694 

 

Department:      Center for Gene Therapy

Research Institute at Nationwide Children’s Hospital

Columbus, Ohio, USA

   

About Columbus and the Center for Gene Therapy  

Columbus is the state capital of Ohio. It is the 14th largest city in the United States with a population of 892,533 as of 2018 estimates, and is one of the fastest growing large cities in the United States. To know more about Columbus city and surrounding, visit https://www.experiencecolumbus.com/

 

The city hosts The Ohio State University which grown into the third-largest university campus in the United States. In addition, the city also hosts the Research Institute at Nationwide Children’s Hospital (RINCH) about 2 miles south of The Ohio State University Campus. It is composed of three research buildings that are adjacent to clinical and educational facilities. Based on NIH funding among children’s hospitals in the United States, RINCH is ranked in the top 10. It is also one of the fastest growing pediatric research institutes in the US. More than 100 faculty scientists conduct their work in 13 research Centers of Emphasis. RINCH has excellent programs to support early stage investigators. Finally, RINCH also offers postdocs career development programs for career paths in and outside of academia, supporting networking, grant writing, manuscript preparation, and lab management with courses and workshops. Visit https://www.nationwidechildrens.org/research to learn more about the research pursue at RINCH.

 

Among the 13 center of emphasis, The Center for Gene Therapy in particular promotes basic, translational, and clinical research and is one of the world leading centers for neuromuscular gene therapy. It also provides important resources that can be shared within the national muscle biology and neuromuscular research communities, and is tightly integrated to foster the development of new therapies for muscular dystrophies and other neuromuscular diseases. The Center hosts weekly muscle pathology review sessions, the monthly Research in Progress series, and several larger monthly seminars with distinguished speakers invited from other departments or universities. To learn more about our center, visit https://www.nationwidechildrens.org/research/areas-of-research/center-for-gene-therapy

Why Nationwide Children's Hospital?

The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Children’s Hospital, where Passion Meets Purpose.

Here, Everyone Matters. We’re 13,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world we’ll never even meet. Kids who are living healthier, fuller lives because of the knowledge we share. We know it takes a Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research. Anywhere.

Ask anyone with a Nationwide Children’s badge what they do for a living. They’ll tell you it’s More Than a Job. It’s a calling. It’s a chance to use and grow your talent to make an impact that truly matters. Because here, we exist simply to help children everywhere.

Nationwide Children’s Hospital. A Place to Be Proud

Responsibilities

What Will You Be Doing?

  • Performs research experiments independently (after training period) in accordance with protocols approved by the principal investigator.  Such experiments will involve the use of laboratory animals.
  • Handling, breeding, behavior testing, injecting, dissecting mice, and mounting tissue for use in research studies, as applicable. Molecular biology and cell culture skills are also required. Such activities may be performed independently and may require evening and weekend hours.
  • Ensures accuracy of laboratory analytical procedures as required by specific research projects.
  • Collects and controls experimental data; and maintains accurate daily logs of experiments including purpose of the experiments, methods, results, conclusions and future direction.
  • Interprets the results of data analyses with input from the principal investigator.
  • Prepares abstracts, annual reports, scientific papers, grant applications, and presentations. Experience in statistical analysis and figure making preferable.
  • Train other laboratory workers and students in standard methods, practices, procedures, and equipment operations.
  • Maintains a clean working area and performs general laboratory maintenance.  Adheres to proper safety techniques and procedures.
  • Performs other duties as required for scientific excellence in the research program.

Qualifications

What We Are Looking For?

  • PhD or MD in Molecular Biology or related discipline
  • Molecular biology (cloning, qPCR, IF, WB)
  • Mouse colony experience required
  • Experience in neuroscience and/or gene therapy preferred but not required

Percent of time spent on:

  • 65% Bench work
  • 15% Interpreting results of data analyses with PI
  • 10% Miscellaneous paperwork associated with research
  • 5% Instructing other lab personnel
  • 5% Ordering supplies

Minimum physical requirements:

  • 100% Kneeling / reaching
  • 100% Finger dexterity
  • 100% Talking / hearing / seeing
  • 33%    Lifting / carrying weight 0-20 pounds for 1-5 minutes

The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification.  It is not to be construed as an exhaustive list of duties performed by the individual so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under his/her supervision.

 

EEO/M/F/Disability/Vet

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